The game was originally released in North America by Taito. Sting developed it, with Hideki Takahagi as the main music composer for the Jetsons game, using Mitsuhito Tanaka's primary sound driver for Sting. This game was considered the very last one that used Mitsuhito Tanaka's primary sound driver for Sting until they were ordered by Square Co. Ltd to get rid of that sound driver and create a brand new one for Treasure Hunter G.

In 1995, Kadokawa Shoten created a new manga called Yōkai Buster Ruka and they wanted Sting to reprogram and edit the Super NES Jetsons game and turn it into a new game called Yōkai Buster: Ruka no Daibōken (妖怪バスター ルカの大冒険, lit. "Phantom Buster: Ruka's Big Adventure") with new music (composed by Mitsuhito Tanaka), new enemies and new areas. Both versions have essentially the same engine with a different story and theme. They also have a strict time limit that punishes tardiness with lost lives.

North American version

Captain Zoom informs George while was traveling to work that Zora, the leader of the space pirates, is planning on looting the solar system of all of its resources. George has to go through nine stages of intergalactic action in order to stop the pirates using a special device known as a Pneumo Osmatic Precipitator (P.O.P.). This device allows George to hold on to things and breathe underwater as well. There are various boss fights with machinery. With a high enough score, the player goes into a bonus stage where items must be collected before time runs out. Players must also travel through tubes to get from one part of the level to another. Speed chases are also included in certain levels of the game.

A few of the enemies in this game were not brought over into the Japanese version; like the bomb-dropping/vacuum robot.

Japanese version

The player takes take control of Ruka-chan, an aggressive demon girl who lives in a world filled with harmful monsters. Much of her past is shrouded in mystery and her age is deliberately hidden in context. She lives a long life but has the mentality of a 13-year-old girl. This game had more fluidity and had better gameplay than the North American version. Compared to the futuristic setting of The Jetsons, the Japanese version uses a contemporary setting with Japanese architecture. Extra features were added into the Japanese version including an extra underwater level, a mini-game, and a training mode.

• The Jetsons: Cogswell's Caper!
• The Jetsons video games
• List of Hanna-Barbera-based video games