Jake Westboro is a man with it all: wife, a kid and a house in the suburbs. He also has a job with the Blackburn Tobacco Company. As a result of smoking since he was 15, Jake is dying from the cigarettes that he once sold; the player must help the near-microscopic surgeon Rex Ronan travel inside of Jake's body and remove tar, nicotine, precancerous cells, and other health hazards that are preventing Jake from speaking to the world about the hazards of tobacco. If the player (Rex Ronan) dies from the evil microbots that were sent by the tobacco company, so does the patient (Jake.)

Richard M. Satava mentioned two evaluations in which a number of children (none of whom were more than 12 years old) played a prototype version of the game. The average of the results indicated children who experienced enjoyment and who also showed an interest with regard to acquiring information about tobacco's effects on people. According to Richard L. Street and Timothy R. Manning, the target audience was children and teenagers in the age range of 10 to 16 years. In addition, when it comes to persons who take up smoking, those in the age range of 10 to 16 years are at the highest risk, according to Street and Manning.