Indiana Jones & The Last Crusade: The Action Game was released in 1989 for the DOS, Amiga, Amstrad CPC, Atari ST, Commodore 64, Game Boy, NES, Sega Master System, Mega Drive/Genesis, Sega Game Gear, MSX and ZX Spectrum. Each version of the game is similar, with slight differences in the quality of the graphics and sound. This is a side-scrolling adventure game where players control the Indiana Jones through various side-scrolling levels from the film, armed with their reflexes and the trademark whip.

Indiana Jones & The Last Crusade: The Graphic Adventure is a popular graphic adventure game (similar to Maniac Mansion or The Secret of Monkey Island) released by LucasArts for DOS, Amiga, Atari ST and Macintosh systems in 1989. The player controls Dr. Jones as he interacts with various characters and visits areas from the film in order to find the secret of the Holy Grail. The game was re-released twice - first with 256 colour graphics and a full digital soundtrack, and later with 256 colour graphics, minor bugfixes and the original version's MIDI soundtrack. Of all the software adaptions of the film, this one is the most popular with both gamers and critics alike.

A second NES game was produced by Taito based on the same film, released only in North America. It is a side-scrolling action adventure game, mixed in with some mini-games involving timed puzzles. The player can also follow some segments of the story and decide which order the character will play each scenario.

The Last Crusade is the last part of this Super NES game, which is based on the first three Indiana Jones movies.