George, Lizzie, and Ralph have been captured and confined for the world to see. George is held captive in New York City, Lizzie is imprisoned in Tokyo, and Ralph the Wolf is stored in London (references to King Kong, Godzilla, and Werewolf of London (or An American Werewolf in London), respectively). However, Scumlabs, who has just rebuilt their facilities in Salt Lake City, causes another accident that results in three new monsters: Boris, a rhinoceros, Curtis, a mouse, and Ruby, a lobster. Players choose one of the three original monsters to rescue. The player then uses the characters in the part of the world where the rescue is held. They work as a collective to break buildings, eat people, and destroy cars and this creates competition among players. When a player (literally) unlocks George, Lizzie, or Ralph, then they become playable characters. Once all the monsters are rescued, aliens begin to invade the earth, leaving the monsters the only ones who can save the planet they just helped partially destroy. After fending off the invasion on Earth, the monsters rescue Myukus (a green cyclops-like alien, Noobis is his purple pallete swap.) from Area 51 before chasing the aliens through space, destroying the aliens' bases throughout the Solar System and eventually rampaging through their homeworld and destroying their capitol. During the game, players can see the two developing love stories of George and Ruby and Curtis and Lizzie.

A news channel covers all the monsters destroy and tear up. At the end of the game, it is revealed that the aliens have a news program, but the alien anchorman who runs the program is eaten by Myukus.

United States

• Salt Lake City
• Denver
• Seattle
• San Francisco
• Los Angeles
• San Diego
• Las Vegas
• Phoenix
• Dallas
• San Antonio
• Houston
• Kansas City
• New Orleans
• St. Louis
• Miami
• Atlanta
• Cincinnati
• Cleveland
• Chicago
• Pittsburgh
• Detroit
• Philadelphia
• Boston
• Washington D.C.
• New York City

Asia

• Beijing
• Pyongyang
• Seoul
• Shanghai
• Hong Kong
• Taipei
• Kaoshiung
• Guangzhou
• Hanoi
• Rangoon
• Bangkok
• Phnom Pehn
• Kuala Lumpur
• Singapore
• Jakarta
• Brunei
• Manila
• Fukuoka
• Osaka
• Yokohama
• Kobe
• Nagano
• Sapporo
• Sendai
• Tokyo

Europe

• Madrid
• Barcelona
• Monte Carlo
• Geneva
• Brussels
• Paris
• Luxembourg
• Amsterdam
• Hamburg
• Frankfurt
• Munich
• Zurich
• Florence
• Rome
• Athens
• Vienna
• Prague
• Warsaw
• Berlin
• Copenhagen
• Stockholm
• Edinburgh
• Dublin
• Manchester
• London

Global Alien Invasion

• Delhi
• Perth
• Melbourne
• Sydney
• Honolulu (alien buildings begin to appear)
• Mexico City
• Havana
• Panama City
• Caracas
• Lima
• Buenos Aires
• Rio de Janeiro
• Johannesburg
• Nairobi
• Abu Dhabi
• Cairo
• Moscow
• Helsinki
• Istanbul
• Lisbon (all alien buildings from here onward)
• Toronto
• Calgary
• Anchorage
• Vancouver
• Area 51 (no alien buildings)

Note: Not all stages from Honolulu through Istanbul have alien buildings. Stages that do have only 1 or 2 and will be uninhabited.

Solar System and Milky Way Galaxy

• Moon
• Mercury
• Venus
• Mars
• Phobos
• Saturn
• Io
• Europa
• Neptune
• Jupiter
• Halley's Comet
• Uranus
• Pluto

Alien Homeworld

• Drapheus
• Skinsonatti
• Les Vegees
• Housteenk
• Cornholens
• Spamburgh
• Uranelphia
• Newd Yoke
• Wazelskown
• Yokmiyama
• Flachulas

Most of the cities in each level are built according to their real-world appearances:

• In London, one of the structures that could be destroyed is the Tower of London. Another is Big Ben.
• In Washington, D.C., one of the buildings that could be destroyed looks like the White House, and another looks like the Capitol.
• In New York, the Chrysler Building, Empire State Building, and World Trade Center, could be destroyed as well, the game having taken place before the terrorist attacks on September 11, 2001.
• In Chicago, the Willis Tower, formerly the Sears Tower, can be destroyed.

Most of the fake planets are named after real cities.

Reception

IGN rated the game 5.3, criticizing it as being "repetitive".