Earthworm Jim: Menace 2 the Galaxy is the fourth and final platform video game in the Earthworm Jim series. It was released on November 16, 1999 for the Game Boy and Game Boy Color. It was very poorly received, and no new original Earthworm Jim games have been released since its release.

Evil Jim has kidnapped Princess What's-Her-Name and Earthworm Jim must embark on yet another adventure to save her. The game involves the player directing Jim through the levels in order to do so. The game plays as a 2D sidescrolling platformer with elements of a run and gun, similar to how the original Earthworm Jim and Earthworm Jim 2 played. However, the game has been greatly simplified, the game is much more centralized towards exploring levels to collect items, rather than the constantly changing gimmicks present in the original two games. Levels typically involve goals such as collecting 100 or more coins to progress through levels, and if the player leads jim to take too much damage, the player must start the level over again, with zero items collected.

The game does retain some features from past games though. Four different guns can be collected and used to defeat enemies; the standard gun, plasma gun, rocket launcher, and a grenade launcher. Also, player could find Jim's friend, Snott, and ride him to jump higher, or obtain Jim' rocket, which allows fly and shoot across the level for a small amount of time.

After every two levels, Jim would have to face a boss that featured enemy characters from past games and the Earthworm Jim television series, which include Bob the Killer Goldfish, Evil the Cat and Henchrat, Queen Slug-for-a-Butt and Evil Jim.

The game is compatible with both the Game Boy and Game Boy Color video game consoles. However, the level named "Happiness" is only available if the game is played on the Game Boy Color, being playable upon the game's completion.