Marvel Super Heroes: War of the Gems (マーヴルスーパーヒーローズ ウォーオブザジェム) is the title of a 2D action platformer video game for the Super Nintendo Entertainment System based on the events of Marvel Comics' series, Infinity Gauntlet. In the game's plot, Adam Warlock calls upon Earth's greatest super heroes to seek out the Infinity Gems before they fall into the wrong hands.

Although War of the Gems is based on the same storyline as the Capcom arcade game Marvel Super Heroes, it is not a port; War of the Gems instead features gameplay similar to X-Men: Mutant Apocalypse.

The player plays each level as one of five superheroes - Captain America, Iron Man, Spider-Man, Wolverine, or Hulk - as they battle through various locations around the globe and even outer space. Each character's health bar is separate and carries over between missions - healing can only be done by picking up items in the levels or using healing items picked up during missions. When a character falls, they must be revived individually with the appropriate item.

After investigating an area, the player may or may not be rewarded with one of the gem resulting in a restart of the entire game. Only two can be picked up during the first four missions, one is picked up in the following mission, and then two more are randomly received in two of the four following levels. The last gem is only received upon defeating Thanos, thus completing the game.

A training hologram level in the game is The Avengers Mansion where players can practice fighting certain bosses of the game. Sometimes, he will be rewarded with an item for succeeding (and sometimes when a character succeeds in getting an item based on how well he performed will determine the item received.) Each character can also execute special attacks with command input similar to fighting games, but slightly simplified.