Handheld

• The Powerpuff Girls: Bad Mojo Jojo was developed by Sennari Interactive for the Game Boy Color. It was released in North America on November 14, 2000.Bad Mojo Jojo follows Blossom, the leader of the Powerpuff Girls, as she fights Mojo Jojo and his henchmen. Blossom can fly, but only for a short period of time. GameSpot cites this as a key problem, as whenever Blossom falls into water, she not only dies, but any progress in collecting required trinkets throughout the level is reset to nothing. Another aspect of the game is that the player takes the role of Bubbles, Buttercup, Rowdyruff Boys Brick, Boomer, Butch, and the Mayor of Townsville through the use of entering passwords, which can also be used to unlock special features like unlimited flight.

• The Powerpuff Girls: Paint the Townsville Green was developed by Sennari Interactive for the Game Boy Color. It was released in North America on November 28, 2000. Unlike the previous game, this installment follows Buttercup. The game plays very similar to the first one, for the sake of being able to trade cards between the two games when they're linked together.

• The Powerpuff Girls: Battle HIM was developed by Sennari Interactive for the Game Boy Color. It was released in North America on February 27, 2001. Unlike the other two games, Battle HIM follows Bubbles, and plays very similar to the first two, for the sake of being able to trade cards between the three when two are linked together.

• The Powerpuff Girls: HIM and Seek was developed by Vicarious Visions for the Game Boy Advance, released on October 29, 2002. Styled as an RPG, you play as all three girls searching for scavenger hunt items while fighting Mojo Jojo, Fuzzy Lumpkins, Princess Morbucks, The Gangreen Gang, and HIM.

• The Powerpuff Girls: Mojo Jojo A-Go-Go is the Powerpuff Girls animated series based video game. It centers around the name of the Power Girls' mission to stop Mojo Jojo and his minions. In the three adventure hero alternately until the game is a transparent or all three of the hero is lost energy. The game developed by Sennari Interactive in 2001 and it is only available for the Game Boy Advance.

• Game de Demashita! Powerpuff Girls Z (ゲームで出ましたっ！ パワパフ ガールズ Z, Gēmu de Demashita! Pawāpafu Gāruzu Zetto) is a party videogame based on the spin-off series, Powerpuff Girls Z, which was released exclusively in Japan for the Nintendo DS on June 12, 2007.

Console

• The Powerpuff Girls: Chemical X-traction was developed by VIS Entertainment. It was released in North America for the Nintendo 64 (N64) on October 14, 2001, and for the PlayStation on November 8, 2001. The Powerpuff Girls must battle enemies in a variety of settings in order to reclaim Chemical X and track down Mojo Jojo. Players can play the story mode or can battle against a friend in a head-to-head battle. In the story mode, players can pick up objects and throw them at an enemy to decrease their opponents health meter. They can use superpowered attacks by collecting vials of Chemical X. If the player successfully defeats the enemy in two out of three rounds, they move to the next enemy location.

• The Powerpuff Girls: Relish Rampage is a game developed by VIS Entertainment. It was originally released on the PlayStation 2 on November 24, 2002 in North America, and December 13, 2002 in Europe, but was later produced for the GameCube in Europe on December 13, 2002 and in North America on October 15, 2003. In the game you play the 3 Powerpuff Girls, and must fly around a 3D world solving puzzles in an attempt to stop the invasion of Townsville by Pickles from outer space.

PC

• The Powerpuff Girls: Mojo Jojo's Clone Zone is a PC learning game published by The Learning Company, for ages 6+. The Powerpuff girls are supposed to defeat a bunch of Mojo Jojo clones and get their motherboards to earn various prizes and more.

• The Powerpuff Girls: Gamesville was developed by BAM! Entertainment for the PC-CD-ROM. It was released on October 31, 2002.

• The Powerpuff Girls: Princess Snorebucks is a PC game made by The Learning Company. In it, the girls are asleep and you must fight through their nightmares to get through the stages.

• The Powerpuff Girls: Mojo Jojo's Pet Project is a PC adventure game published by BAM! Entertainment. In the game, the controller plays the three girls (Blossom, Bubbles, and Buttercup), as well as their new supercomputer in an array of arcade-style games to save Townsville from mutated animals.

Other appearances

• Cartoon Network: Punch Time Explosion/XL is a game developed by CRAVE Games and is currently available for the 3DS (original version only) and consoles (XL version only) systems, it released since June 2, 2011. Though not a main Powerpuff Girls game, it still features all three girls, Mojo, and Him as playable characters, Fuzzy Lumkins as an assist character, The Rowdyruff Boys as the girls' alternate costumes, and the show as a stage.

• Cartoon Network Racing is a game is a creation of Cartoon Network Interactive, Eutechnyx, Firebrand Games and The Game Factory. It is for the PlayStation 2 and the Nintendo DS. Though not a main Powerpuff Girls game, it still features all three girls, Mojo, HIM, Fuzzy Lumkins and Professor Utonium as playable characters, it released since November 28, 2006.

• Cartoon Network Universe: FusionFall is a massively multiplayer online game developed by Cartoon Network and Grigon Entertainment. FusionFall uses the Unity engine as its client technology basis. It is for the web-browser based game. Though not a main Powerpuff Girls game, it still features all three girls, Mojo, HIM, Fuzzy Lumkins, Princess Morbucks, Ace, the Mayor and Professor Utonium as non-playable characters(NPCs), it released since January 14, 2009.

Bad Mojo Jojo was a failure critically. IGN gave the game a 5.0, and wrote that, "It really boils down to a game where you fly around and collect icons thrown in different parts of the levels."GameSpot rated the game a 3.2 ("bad" rating), and reported, "Even younger players will find the game to be little more than an exercise in frustration."

Paint the Townsville Green earned mixed reviews. GameSpot gave the game a 5.7 out of 10.

Battle Him earned mixed reviews with a score of 5 out of 10 from GameSpot.

Relish Rampage received mixed reviews for the GameCube version, but negative reviews for the PS2 version. Metacritic gave the game a 46 out of 100 based on 5 reviews for the PS2 version and, for the GameCube version, giving it a score of 51 out of 100 based on 3 reviews.

Mojo Jojo-A-Go-Go received mixed reviews. Metacritic gave the game a 60 out of 100 based on 11 reviews. GameSpot gave the game a 6.3 saying; "While the game can't be recommended as highly as the incredible cartoon it's based on, Powerpuff Girls: Mojo-Jojo A-Go-Go is a capable shooter in its own right."

IGN gave the PS1 version of Chemical X-traction a "terrible" 2.0 out of 10 overall, criticizing the gameplay stating it was weak and the graphics saying "The goggles do nothing!" while though they praised the presentation and the sound of the game.

• List of Cartoon Network video games