Mega Man Xtreme 2, known as Rockman X2: Soul Eraser (ロックマンX2 ソウルイレイザー) in Japan, is a video game developed by Capcom for the Game Boy Color handheld game console. It is a spin-off title in the Mega Man X series and is a follow-up to Mega Man Xtreme, released the previous year. Mega Man Xtreme 2 takes place during the 22nd century, in an unknown year 21XX, between the events of Mega Man X3 and Mega Man X4. The DNA souls of robots known as "Reploids" all around the world are being stolen by pair of villains in order to create an army of undead "Mavericks". The "Maverick Hunters" Mega Man X and Zero quickly spring into action, now with the help of their young ally Iris.

Mega Man Xtreme 2 is a similar take on the series action and platforming gameplay formula while combining elements from home console versions of the Mega Man X series. The player may choose to play each of a series of stages as either protagonist, X or Zero. Defeating the stage's boss will earn that player character its special weapon. Critical reception for Mega Man Xtreme 2 was lightly positive, with most reviewers giving the game praise typical of the long-running series and noting a general improvement over the first Mega Man Xtreme title.

Mega Man Xtreme 2 is an action-platform game that plays very similar to the first Mega Man Xtreme. Like the Game Boy incarnations of the classic Mega Man series, Mega Man Xtreme 2, reuses elements from first three home console Mega Man X games. The player is tasked with completing a series of side-scrolling levels by avoiding obstacles and destroying end-stage bosses. Stages are typically linear and present a number of traps and enemy robots to combat; collecting DNA Souls and items that refill health, ammunition, and extra lives; power-ups that improve the player's maximum health; and armor parts that grant X new abilities. Defeating the Maverick boss at the stage's end will earn the player its special weapon. These weapons can then be used to more easily other bosses, as each one is weak to a unique weapon. After each level, the DNA Souls gathered in the level will accumulate, which the player can use to purchase additional upgrades from Iris. These upgrades range from speed and power improvements, health rechargers, and shielding.

In the game's normal difficulty mode, the player is given the option to choose between using X and using Zero, each lending their own advantages and disadvantages. X uses his "X-Buster" to shoot enemies from a distance. It can be charged up to inflict more damage to enemies. Alternatively, Zero uses his "Z-Saber" for close-range combat. Zero risks losing health more often by getting closer to enemies, but his slashes are more damaging than X's bullets. A difficulty setting called "Xtreme Mode" can be unlocked where the player can switch between X and Zero on any level, thus allowing them to gain different weapons depending on which bosses they defeat. The major change in this game compared with other Mega Man X titles is that X and Zero do not both gain a weapon when a boss is defeated; only the character used to destroy the Maverick will get the special weapon. This adds a hint of strategy to the gameplay, as one must consider not only the order in which they will fight each boss, but whether X or Zero's gained weapons will prove more effective later on, and which are needed to gain hard-to-reach power-ups. Beating Xtreme Mode will unlock a "Boss Rush" that allows the player to battle all eight Mavericks from this game as well as the eight Mavericks from the first Mega Man Xtreme.